Trevor Lawrence passed for two touchdowns and Travis Etienne Jr. ran for two scores to lead the Jacksonville Jaguars to a 37-20 victory over the visiting Indianapolis Colts on Sunday afternoon.

Christian Kirk and Brenton Strange caught touchdown passes as Jacksonville (4-2) moved into first place in the AFC South. The Jaguars forced four turnovers on a strip-sack by Josh Allen and interceptions by Andre Cisco, Rayshawn Jenkins and Darious Williams.

Lawrence, who sustained a left knee injury, was 20-of-30 passing for 181 yards, two touchdowns and one interception as Jacksonville finished off the two-game regular-season sweep of the Colts. He injured the knee while being sacked by defensive end Samson Ebukam in the fourth quarter, one play before a 51-yard field goal made it a 37-20 lead for Jacksonville at the 3-minute mark. Lawrence spoke to CBS on the field after the game and entered the locker room under his own power.

Two-time NFL tackles leader Foyesade Oluokun had a season-best 15 stops for the Jaguars.

Gardner Minshew completed 33 of 55 passes for 329 yards, one touchdown and a career-worst three interceptions for Indianapolis (3-3). The former Jacksonville quarterback was starting in place of Anthony Richardson, who was placed on injured reserve with a potentially season-ending shoulder injury.

Zack Moss rushed for a touchdown, Josh Downs had a scoring reception and Julius Brents intercepted a pass for the Colts.

The Colts opened the game with a 16-play, 65-yard drive that lasted 8:33 but ultimately settled for Matt Gay's 28-yard field goal.

The Jaguars seized control with two touchdowns in a span of 16 seconds early in the second quarter and never let up.

Etienne capped a 13-play, 75-yard drive with a 2-yard run 43 seconds into the second quarter to put Jacksonville ahead.

Disaster occurred on the Colts' next offensive play as Allen recorded his seventh sack of the season -- fourth against Indianapolis -- and caused Minshew to fumble and Angelo Blackson recovered at the Indianapolis 22-yard line. On the next play, Etienne scooted 22 yards for a touchdown to give the Jaguars a 14-3 advantage with 14:01 left in the first half.

Jacksonville stretched its lead to 18 when Lawrence threw a 29-yard touchdown pass to Kirk with 1:40 left in the half. Gay kicked a 56-yard field goal with 6 seconds remaining as the Colts trailed 21-6 at the break.

Jenkins intercepted Minshew early in the third quarter to set up a 48-yard field goal by Brandon McManus. Later in the period, Lawrence tossed a 10-yard scoring pass to Strange to make it 31-6 with 3:51 remaining.

The Colts scored a touchdown with 14:14 left in the game when Minshew connected with Downs on a 2-yard scoring pass.

Moss tacked on a 3-yard scoring run to bring the Colts within 31-20 with 7:14 left.

McManus added field goals of 49 and 51 yards for Jacksonville.

--Field Level Media