Steelers 51, Colts 34: Ben Roethlisberger set franchise records with 522 yards passing and six touchdowns to secure his 100th regular-season win in style as Pittsburgh outslugged visiting Indianapolis.

Roethlisberger, who went 40-of-49, became the first quarterback in NFL history to notch two 500-yard performances in his career - with his previous effort going for 503 versus Green Bay on Dec. 20, 2009. His passing total tied Boomer Esiason (1996, Arizona) for the fourth-highest in league history, 32 yards shy of Norm Van Brocklin's mark set versus the New York Yanks on Sept. 28, 1951.

Antonio Brown (10 receptions, 133 yards) and rookie Martavis Bryant each reeled in two touchdown passes, Markus Wheaton made one scoring catch and tight end Heath Miller recorded the last with an 11-yard reception over the middle with 5:14 remaining in the fourth quarter. Cornerback William Gay added a 33-yard interception return for a score as the Steelers (5-3) won their second in a row.

Andrew Luck went 26-of-45 for 400 yards with three touchdowns while setting a franchise record with his sixth straight game of over 300 yards passing. T.Y. Hilton, rookie Donte Moncrief and tight end Dwayne Allen each hauled in a scoring strike and Ahmad Bradshaw added his eighth touchdown of the season for the Colts (5-3), who saw their five-game winning streak come to an end.

After Wheaton's 18-yard touchdown reception gave Pittsburgh a 7-3 lead midway through the first quarter, Bryant had a scoring grab over the middle on the first play of the second quarter for his second TD in as many weeks. Just 41 seconds later, Gay intercepted Luck after jumping in front of Hakeem Nicks before going untouched to the end zone to give the Steelers a 21-3 lead.

Indianapolis rebounded on the ensuing drive as Allen reeled in a 21-yard reception for his sixth touchdown in eight games before Brown made a one-handed grab for an 8-yard score and a 47-yard jaunt for another to put Pittsburgh up 35-10. The teams traded touchdowns before Bradshaw scampered in from 12 yards out with 3:38 left in the third and Moncrief added a 31-yard TD reception just 63 seconds later.

GAME NOTEBOOK: Indianapolis LB Andy Studebaker recovered a fumble by Pittsburgh RB LeGarrette Blount early in the fourth quarter, but Luck was whistled for intentional grounding while in the end zone for a safety to push the Steelers' lead to 44-34. ... Indianapolis' Adam Vinatieri became the first kicker in NFL history to successfully make 200 field goals for two different franchises when he opened the scoring in the first quarter with a 31-yard kick. Vinatieri also booted 263 field goals for New England. ... Brown extended his NFL record to 24 straight games with at least five receptions and 50 yards.