Colts 41, Titans 17: Andrew Luck threw four touchdown passes for the second straight game as host Indianapolis cruised past Tennessee.

Luck was 29-of-41 for 393 yards, one week after throwing for 370 yards and four scores in a lopsided victory over Jacksonville. Reggie Wayne had seven catches for 119 yards and a touchdown while T.Y. Hilton contributed six receptions for 105 yards for the Colts (2-2).

Playing in place of Jake Locker (wrist), Charlie Whitehurst was 12-of-23 for 177 yards with one touchdown and one interception for Tennessee.. Whitehurst led the Titans (1-3) with 40 rushing yards while tight end Delanie Walker contributed 84 receiving yards and a score.

Following a fumble by Titans receiver Kendall Wright, the Colts took an early 7-0 lead as Trent Richardson plunged in from 1 yard out before Indianapolis perfectly executed a surprise onside kick - which led to Luck's 7-yard TD strike to tight end Dwayne Allen. Whitehurst was intercepted on the second play of the second quarter and the Colts capitalized on Adam Vinatieri's 31-yard kick to make it 17-0.

Tennessee closed within 20-10 at halftime on Whitehurst's 7-yard TD strike to Walker with 13 seconds left in the second quarter, but Indianapolis regained control on Luck's 28-yard TD pass to Wayne midway through the third. Luck tacked on a 2-yard TD pass to tight end Coby Fleener and a 15-yard scoring strike to Ahmad Bradshaw in winning for the 11th time in the last 12 meetings between the teams.

GAME NOTEBOOK: Wayne passed Isaac Bruce (1,024) for seventh on the NFL's all-time receptions list and Henry Ellard (13,777) for 10th all-time in receiving yards. ... Richardson carried 20 times for 47 yards while Bradshaw contributed 32 yards on nine carries. Richardson also had four catches for 52 yards. ... Colts LB D'Qwell Jackson led all players with 10 tackles and also had one of his team's three sacks.